Synapsin 1 promoter

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August undefined, 2024

WebThe cre/LoxP system can produce conditional loss of gene function in specific cell types such as neurons. A transgenic mouse line, utilized by multiple studies, used the Synapsin I promoter to drive expression of cre (SynCre) to achieve neuronal-specific cre expression. Herein we describe that cre e … Web003966 B6.Cg-Tg(Syn1-cre)671Jxm/J Specific cre expression in neuronal cells of these mice is controlled by the rat Synapsin I promoter. These mice may be useful when mated to floxed genes of interest in studies of neural development and disorders such as Neurofibromatosis type 1. For Cre-lox experiments, researchers should assay all of the …

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WebIn the present study, I investigated the brain-region-specific proteome profile of transgenic p60TRP mice overexpressing p60TRP under synapsin-1 promoter using 2D-LCMS/MS-iTRAQ to gain an insight ... WebPlasmid pLV-hSyn1-GFP from Dr. Christopher Grigsby's lab contains the insert CopGFP inserted behind human synapsin I promoter and is published in Biomater Sci. 2024 Aug 7;9(15):5175-5191. doi: 10.1039/d1bm00400j. Epub 2024 Jun 15. This plasmid is available through Addgene. boots petite range glasses

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WebNational Center for Biotechnology Information WebHere, we show that by using a small fragment of the human synapsin 1 gene promoter, we were able to restrict transgene expression from an adenoviral vector exclusively to … WebJun 23, 2024 · Kügler S, Kilic E, Bähr M. Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat … hatland

The Diverse Roles of TIMP-3: Insights into Degenerative Diseases …

Systemic AAV9 gene therapy using the synapsin I promoter …

WebSynapsin 1 was rarely observed along the neural processes of both the hiPSC- and hESC-derived neurites making contact with hair cells. ... and reduces alpha-syn. Inducible H4 cells that express alpha-syn under the control of a tetracycline-responsive promoter (tet-off) were treated with 10 mu m 758 and harvested 3 d later. WebA segment of the human alpha 1-antitrypsin (alpha 1AT) 5'-flanking region comprising nucleotides -137 to -37 from the start of transcription is sufficient to drive liver-specific … boots petty cury cambridge opening timesWebDec 21, 2024 · TIMP-3, the focus of this review, is found in chromosome 22q12.3 and is nested within an intron of the gene synapsin 3 (SYN3); a feature shared with TIMP-1 and TIMP-4 which are located within introns of synapsin 1 (SYN1) and synapsin 2 (SYN2), respectively . TIMP-2 however, is not associated with any of the synapsin genes. hatlab trappes

"WebAug 1, 2024 · Summary. This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of … " - Synapsin 1 promoter

Synapsin 1 promoter

WebSurprisingly, the synapsin I promoter region from −422 to −235 did not show any effect upon transcription on its own, as depicted in Fig. 5B. We postulate that this sequence requires … WebSep 10, 2016 · The ability to transfer a target gene into a specific cell type is an essential aspect of biomedical research. The specific expression of ChR2opt in this work would be useful for the field of optogenetics. The human synapsin 1 promoter confers neuron-specific transgene expression (Kügler et al., 2003).

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WebHere we investigate which cells within the testis express a transgene consisting of the rat synapsin 1 promoter fused with luciferase. Synapsin 1-luciferase expression vectors were … WebOct 11, 2024 · The synapsin I promoter and the α-CaMKII promoter drove TagRFP expression in more than 80% of the total neurons including a considerable fraction of …

WebDec 17, 2004 · Because Synapsin I expression peaks between the second and third postnatal week , the Synapsin I-based vectors may be suitable for early postnatal expression. To evaluate this possibility, we compared EGFP expression from α-CaMKII (1.3 kb) and Synapsin (1.1 kb) promoters during the second postnatal week.

WebhSyn promoter. This biomodule encodes for Human synapsin 1 gene promoter (hSyn). hSyn confers highly neuron-specific long-term transgene expression in the adult rat brain. The AAV collection was developed by Sirion Biotech AG and is made available for research purposes only. Unless pursuant to a separate, written agreement with Sirion Biotech ... WebOct 7, 2013 · Synapsin 1 (SYN1) is a phosphoprotein involved in nerve signal transmission. The porcine SYN1 promoter orthologue was cloned and characterized to provide a means …

WebJustia Patents US Patent Application for COMPOSITIONS AND METHODS FOR PRODUCTION OF RECOMBINANT ADENO-ASSOCIATED VIRUS Patent Application (Application #20240111672)

WebSummary. This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. … hatland 8 1/4WebOct 28, 2024 · However, O. vulgaris synapsin C domain has two glutamate residues at the ATP binding site (Glu347 and Glu360), similarly to synapsin I (where the corresponding residues are Glu373 and Glu386) and ... hatland 81/4WebMar 1, 2005 · Synapsin 1-luciferase expression vectors were introduced into HeLa cells, into TM3 cells derived from mouse testicular Leydig cells, and into one-cell embryos to make transgenic mice. Indirect ... boots petersfield high streetWebCreative Biolabs offers high-quality MS 275 to boost neuroscience research. hatland bushwalker hoedWebJan 10, 2024 · Expression profile following intravenous administration of 2 × 10 11 vg AAV9.hSYNI.eGFP to neonatal mice. (A) Representation of the single-stranded AAV9 … boot speyerWebAug 11, 2024 · Promoters can also drive different levels of expression. For example, CAG is a strong promoter that drives very high, ubiquitous expression, while the human synapsin 1 promoter is neuronal specific (Haery et al., 2024). Most AAV transfer plasmids have a promoter, but this element isn’t required when the transfer plasmid harbors non-coding ... hat laborWebFeb 10, 2003 · The human synapsin 1 gene promoter targets long-term expression of the EGFP reporter gene exclusively to neurons. A dose of 10 7 PFU of each vector was … boots pfizer