Circanks1b

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August undefined, 2024

WebNational Center for Biotechnology Information WebScale bar = 10 μm. g qRT-PCR for the expression of circANKS1B in 40 normal tissues and 165 breast cancer tissues. h Analysis of circANKS1B expression in breast cancer patients with or without ...

Circular RNAs: implications of signaling pathways and …

WebMar 16, 2024 · Circular RNAs (circRNAs) are an emerging class of endogenous RNAs abundantly expressed in eukaryotic cells.These molecules are generated from precursor mRNAs through non-canonical splicing and are widely expressed in diverse species.circRNAs include exonic circRNAs, exon-intron circRNAs (EIciRNAs), and … We characterized circRNA transcripts by performing RNA-seq on ribosomal RNA-depleted total RNA from three pairs of TNBC and adjacent normal tissues. In all, 69,815 distinct circRNAs were found in this study and 87% were derived from exons, and the others were derived from introns, intergenic region and 3′ … See more To dissect the underlying mechanism by which circANKS1B induces EMT to promote breast cancer metastasis, we mainly focus on “miRNA sponges” because of … See more USF1, a transcription factor, belongs to the basic helix-loop-helix leucine zipper (bHLH-LZ) family which regulates different genes expression by … See more first plus elderbridge loan complaints

The pro-metastasis effect of circANKS1B in breast cancer

WebD L, R Y, L Y, D W, X Z, Y S: circANKS1B regulates FOXM1 expression and promotes cell migration and invasion by functioning as a sponge of the miR-149 in colorectal cancer. OncoTargets and therapy 2024, 12(undefined):4065-4073. WebMar 10, 2024 · Epithelial-to-mesenchymal transition (EMT) is a dynamic program of cell plasticity aberrantly reactivated in cancer. The crosstalk between tumor cells and the tumoral microenvironment (TME) has a pivotal importance for the induction of the EMT and the progression toward a malignant phenotype. Notably, exosomes are key mediators of this … first plus parking ticket

Functional roles of circular RNAs during epithelial-to …

WebFeb 21, 2024 · Breast cancer is the second most reported cancer in women with high mortality causing millions of cancer-related deaths annually. Early detection of breast cancer intensifies the struggle towards discovering, developing, and optimizing diagnostic biomarkers that can improve its prognosis and therapeutic outcomes. Breast cancer … WebFurthermore, circANKS1B also acts as a sponge of miR-149 to promote colorectal cancer cell migration and invasion . Analogously, circANKS1B can sponge miR-148-3p and … first plymouth choirWebView 18 photos for 801 S Cranbrook Cir, Wichita, KS 67207, a 3 bed, 3 bath, 1,124 Sq. Ft. single family home built in 2000 that was last sold on 06/01/2012. first plumbing great falls mt

"WebBackground: As circular RNAs (circRNAs) have been found to significantly involve in the onset and progression of multiple malignant tumors including breast cancer (BC), this study aims at evaluating the diagnostic and prognostic values of circRNAs in this malady. Methods: Available databases were thoroughly searched to collect studies on the … " - Circanks1b

Circanks1b

WebJul 15, 2024 · The high expression of circANKS1B is closely related to the clinical stage and is an independent risk factor for the overall survival rate of breast cancer patients. At the same time, breast cancer patients with high expression of ESRP1 also have a poor overall survival . In oral squamous cell carcinoma (OSCC), circUHRF1 is significantly up ... WebFurthermore, the knockdown of circANKS1B sensitized OSCC cells to cisplatin by suppressing cell viability and increasing cell apoptosis and caspase-3 activity. …

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WebNov 19, 2024 · CircANKS1B (a circRNA originated from exons 5 to 8 of the ANKS1B gene, hsa_circ_0007294) was identified by RNA-sequencing and validated by qRT-PCR and … WebThis study aims to investigate the expression and function of circANKS1B in prostate cancer (PC).Methods:

WebFeb 8, 2024 · The expression of circANKS1B and miR‐152‐3p was analyzed by real‐time quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR). Cell migration and invasion were measured using a transwell assay. The interaction between circANKS1B and miR‐152‐3p was confirmed by a dual‐luciferase reporter gene assay. Webcancer patients [18]. Furthermore, circANKS1B also acts as a sponge of miR-149 to promote colorectal cancer cell migration and invasion [19]. Analogously, circANKS1B can sponge miR-148-3p and miR-152-3p to activate the TGF-β signaling to accelerate cancer metastasis [18]. Nevertheless, the function of circANKS1B

WebFeb 8, 2024 · The expression of circANKS1B and miR‐152‐3p was analyzed by real‐time quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR). Cell migration … WebMay 11, 2024 · CircANKS1B is able to sponge miR-148a-3p and miR-152-3p, thereby increases the expression of transcription factor USF1, which in turn up-regulates TGF-β1 expression 57.

WebDec 3, 2024 · Consequently, circANKS1B induces EMT by sponging miR-148a-3p and miR-152-3p. 83 Moreover, upregulated circANKS1B expression, which promotes migration and invasion of cancer cells, served as an independent risk factor for poor OS in patients with BC. 83 Other circRNAs, such as circAGFG1, circKIF4A, and circPLK1, are also …

WebNov 28, 2024 · circANKS1B, arising from exons 5 to 8 of the ANKS1B gene, is markedly overexpressed in TNBC compared to normal tissues and other subtypes of BC . Functional experiments have shown that circANKS1B promotes the epithelial-mesenchymal transition (EMT) to facilitate BC invasion and metastasis both in vitro and in vivo, but has no effect … first plymouthWebSep 3, 2024 · CircANKS1B has been demonstrated to be involved in several diseases, like breast cancer and colorectal cancer (Zeng et al., 2024; Li et al., 2024). In Zeng et al.’s (2024) research, they found that circANKS1B could induce epithelial-to-mesenchymal transition (EMT) via activating TGF-β1 signaling pathway in breast cancer. first plus size si swimsuit modelWebNational Center for Biotechnology Information first-plymouth churchWebFeb 11, 2024 · Similarly, enrichment of circANKS1B in HPV-positive cervical cancer exosomes may play a role in influencing cellular migration and invasion. circANKS1B increases the expression of transcription factor USF1, which upregulates TGF-β1 expression resulting in activated TGF-β1/Smad signaling and EMT in breast cancer . first plymouth churchWebMay 11, 2024 · The results suggest that circANKS1B is an interesting circRNAs to study in order to find alternative therapeutic strategies for inhibiting breast cancer metastasis. CircRNAs in lung cancer Lung cancer is one of the most common cancers in the world with 5-year survival rates varying from 92 to 0%, depending on disease stage at diagnosis 58 . first plymouth church on youtubeWebPubMed first-plymouth church lincoln neWebNov 19, 2024 · Increased circANKS1B expression was closely associated with lymph node metastasis and advanced clinical stage and served as an independent risk factor for overall survival of breast cancer patients. Functional studies revealed that circANKS1B promoted breast cancer invasion and metastasis both in vitro and in vivo by inducing epithelial-to ... first plymouth church on colorado blvd